MCM9 Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis. Belongs to the MCM family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC
Chromosomal Location of Human Ortholog: 6q22.31
Cellular Component:  chromosome; MCM8-MCM9 complex; nucleus
Molecular Function:  ATP binding; chromatin binding; DNA binding; DNA helicase activity; enzyme binding; MutLbeta complex binding; MutSalpha complex binding; MutSbeta complex binding; protein binding; protein-containing complex binding
Biological Process:  cellular response to DNA damage stimulus; DNA duplex unwinding; double-strand break repair via homologous recombination; female gamete generation; mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication; protein localization to chromatin; recombinational interstrand cross-link repair
Disease: Ovarian Dysgenesis 4
Reference #:  Q9NXL9 (UniProtKB)
Alt. Names/Synonyms: C6orf61; dJ329L24.1; dJ329L24.3; DNA helicase MCM9; DNA replication licensing factor MCM9; FLJ13942; FLJ20170; FLJ56845; hMCM9; MCM9; MCMDC1; MGC35304; Mini-chromosome maintenance deficient 9; Mini-chromosome maintenance deficient domain-containing protein 1; minichromosome maintenance 9; minichromosome maintenance 9 homologous recombination repair factor; minichromosome maintenance complex component 9; minichromosome maintenance deficient domain containing 1; ODG4
Gene Symbols: MCM9
Molecular weight: 127,313 Da
Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene