MBD4 Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.-
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component:  nuclear speck; nucleoplasm
Molecular Function:  DNA N-glycosylase activity; endodeoxyribonuclease activity; protein binding; pyrimidine-specific mismatch base pair DNA N-glycosylase activity; satellite DNA binding
Biological Process:  depyrimidination; DNA repair; response to estradiol
Reference #:  O95243 (UniProtKB)
Alt. Names/Synonyms: 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; MBD4; MED1; methyl-CpG binding domain 4, DNA glycosylase; methyl-CpG binding domain protein 4; Methyl-CpG-binding domain protein 4; Methyl-CpG-binding endonuclease 1; Methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein
Gene Symbols: MBD4
Molecular weight: 66,051 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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MBD4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene