MAT2A
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Belongs to the AdoMet synthase family. Detected in kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase |
Chromosomal Location of human Ortholog: 2p11.2 |
Cellular Component:
cytosol; methionine adenosyltransferase complex
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Molecular Function:
ATP binding; identical protein binding; metal ion binding; methionine adenosyltransferase activity; protein binding; small molecule binding
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Biological Process:
cellular response to leukemia inhibitory factor; one-carbon metabolic process; protein heterooligomerization; protein hexamerization; S-adenosylmethionine biosynthetic process
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Reference #:
P31153
(UniProtKB)
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Alt. Names/Synonyms: AdoMet synthase 2; adoMet synthetase 2; AMS2; MAT 2; MAT-II; MAT2A; MATA2; MATII; Methionine adenosyltransferase 2; methionine adenosyltransferase 2A; Methionine adenosyltransferase II; methionine adenosyltransferase II, alpha; METK2; S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthetase isoform type-2; SAMS2; testicular tissue protein Li 121
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Gene Symbols: MAT2A
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Molecular weight:
43,661 Da
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Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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