MAT2A Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Belongs to the AdoMet synthase family. Detected in kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase
Chromosomal Location of human Ortholog: 2p11.2
Cellular Component:  cytosol; methionine adenosyltransferase complex
Molecular Function:  ATP binding; identical protein binding; metal ion binding; methionine adenosyltransferase activity; protein binding; small molecule binding
Biological Process:  cellular response to leukemia inhibitory factor; one-carbon metabolic process; protein heterooligomerization; protein hexamerization; S-adenosylmethionine biosynthetic process
Reference #:  P31153 (UniProtKB)
Alt. Names/Synonyms: AdoMet synthase 2; adoMet synthetase 2; AMS2; MAT 2; MAT-II; MAT2A; MATA2; MATII; Methionine adenosyltransferase 2; methionine adenosyltransferase 2A; Methionine adenosyltransferase II; methionine adenosyltransferase II, alpha; METK2; S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthetase isoform type-2; SAMS2; testicular tissue protein Li 121
Gene Symbols: MAT2A
Molecular weight: 43,661 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MAT2A

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein