UVSSA Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage. Belongs to the UVSSA family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component:  chromosome; nucleoplasm
Molecular Function:  protein binding; RNA polymerase II complex binding
Biological Process:  protein ubiquitination; response to UV; transcription-coupled nucleotide-excision repair
Disease: Uv-sensitive Syndrome 3
Reference #:  Q2YD98 (UniProtKB)
Alt. Names/Synonyms: hypothetical protein LOC57654; K1530; KIAA1530; MGC117169; Uncharacterized protein KIAA1530; UV stimulated scaffold protein A; UV-stimulated scaffold protein A; UVSS3; UVSSA
Gene Symbols: UVSSA
Molecular weight: 80,591 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
Select Structure to View Below

UVSSA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB