DNAJA1 Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV. Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Nuclear receptor co-regulator
Chromosomal Location of human Ortholog: 9p21.1
Cellular Component:  cytoplasmic side of endoplasmic reticulum membrane; cytosol; membrane; microtubule cytoskeleton; mitochondrion; nucleus; perinuclear region of cytoplasm
Molecular Function:  ATP binding; ATPase activator activity; C3HC4-type RING finger domain binding; chaperone binding; G protein-coupled receptor binding; Hsp70 protein binding; low-density lipoprotein particle receptor binding; metal ion binding; protein binding; Tat protein binding; ubiquitin protein ligase binding; unfolded protein binding
Biological Process:  negative regulation of apoptotic process; negative regulation of establishment of protein localization to mitochondrion; negative regulation of JUN kinase activity; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein ubiquitination; positive regulation of apoptotic process; positive regulation of ATPase activity; protein folding; protein localization to mitochondrion; regulation of protein transport; response to heat; response to unfolded protein
Reference #:  P31689 (UniProtKB)
Alt. Names/Synonyms: DJ-2; DjA1; DnaJ (Hsp40) homolog, subfamily A, member 1; DnaJ heat shock protein family (Hsp40) member A1; DnaJ homolog subfamily A member 1; DnaJ protein homolog 2; DNAJ2; DNAJA1; DNJA1; hDj-2; HDJ2; Heat shock 40 kDa protein 4; Heat shock protein J2; heat shock protein, DNAJ-like 2; HSDJ; HSJ-2; HSJ2; HSPF4; Human DnaJ protein 2; NEDD7; neural precursor cell expressed, developmentally down-regulated 7
Gene Symbols: DNAJA1
Molecular weight: 44,868 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene