DNAJA1 Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 9p21.1
Cellular Component:  cytoplasmic side of endoplasmic reticulum membrane; cytosol; membrane; microtubule cytoskeleton; mitochondrion; nucleus; perinuclear region of cytoplasm
Molecular Function:  ATP binding; ATPase activator activity; C3HC4-type RING finger domain binding; chaperone binding; G protein-coupled receptor binding; Hsp70 protein binding; low-density lipoprotein particle receptor binding; metal ion binding; protein binding; Tat protein binding; ubiquitin protein ligase binding; unfolded protein binding
Biological Process:  negative regulation of apoptotic process; negative regulation of establishment of protein localization to mitochondrion; negative regulation of JUN kinase activity; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein ubiquitination; positive regulation of apoptotic process; positive regulation of ATPase activity; protein folding; protein localization to mitochondrion; regulation of protein transport; response to heat; response to unfolded protein
Reference #:  P31689 (UniProtKB)
Alt. Names/Synonyms: DJ-2; DjA1; DnaJ (Hsp40) homolog, subfamily A, member 1; DnaJ homolog subfamily A member 1; DnaJ protein homolog 2; DNAJ2; DNAJA1; DNJA1; hDj-2; HDJ2; Heat shock 40 kDa protein 4; Heat shock protein J2; heat shock protein, DNAJ-like 2; HSDJ; HSJ-2; HSJ2; HSPF4; Human DnaJ protein 2; NEDD7; neural precursor cell expressed, developmentally down-regulated 7
Gene Symbols: DNAJA1
Molecular weight: 44,868 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene