HEXIM1 Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Belongs to the HEXIM family. Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  7SK snRNA binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; protein binding; snRNA binding
Biological Process:  activation of innate immune response; heart development; innate immune response; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of signal transduction by p53 class mediator
Reference #:  O94992 (UniProtKB)
Alt. Names/Synonyms: Cardiac lineage protein 1; CLP1; EDG1; Estrogen down-regulated gene 1 protein; FLJ13562; hexamethylene bis-acetamide inducible 1; Hexamethylene bis-acetamide-inducible protein 1; hexamethylene bisacetamide inducible 1; hexamethylene bisacetamide-inducible protein; hexamethylene-bis-acetamide-inducible transcript 1; hexamthylene bis-acetamide inducible 1; HEXI1; HEXIM P-TEFb complex subunit 1; HEXIM1; HIS1; HMBA-inducible; MAQ1; menage a quatre 1; Menage a quatre protein 1; Protein HEXIM1
Gene Symbols: HEXIM1
Molecular weight: 40,623 Da
Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene