FOXI1 Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules. Expressed in kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component:  intracellular membrane-bounded organelle; nucleolus; nucleus
Molecular Function:  DNA binding, bending; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  embryo development ending in birth or egg hatching; inner ear morphogenesis; positive regulation of transcription by RNA polymerase II
Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome
Reference #:  Q12951 (UniProtKB)
Alt. Names/Synonyms: FKH10; FKHL10; forkhead box I1; Forkhead box protein I1; forkhead-like 10; forkhead-related activator 6; Forkhead-related protein FKHL10; Forkhead-related transcription factor 6; FOXI1; FREAC-6; FREAC6; Hepatocyte nuclear factor 3 forkhead homolog 3; HFH-3; HFH3; HNF-3/fork-head homolog 3; HNF-3/fork-head homolog-3; MGC34197
Gene Symbols: FOXI1
Molecular weight: 40,973 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Select Structure to View Below

FOXI1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene