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DEPDC1
May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. Expressed in testis. Up-regulated in bladder cancer cells (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Rac/Rho |
| Chromosomal Location of human Ortholog: 1p31.3 |
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Cellular Component:
nucleus; transcription repressor complex
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Molecular Function:
GTPase activator activity; protein binding
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Biological Process:
intracellular signal transduction; negative regulation of DNA-templated transcription
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Reference #:
Q5TB30
(UniProtKB)
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Alt. Names/Synonyms: 5830484J08Rik; cell cycle control protein SDP35; DEP domain containing 1; DEP domain-containing protein 1A; DEP.8; DEP1A; DEPDC1; DEPDC1-V2; DEPDC1A; FLJ20354; SDP35
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Gene Symbols: DEPDC1
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Molecular weight:
92,960 Da
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Basal Isoelectric point:
8.91
Predict pI for various phosphorylation states
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