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CD276
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. Belongs to the immunoglobulin superfamily. BTN/MOG family. Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 9|9 B |
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Cellular Component:
external side of plasma membrane; membrane
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Molecular Function:
identical protein binding; signaling receptor binding
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Biological Process:
negative regulation of inflammatory response; negative regulation of interleukin-2 production; negative regulation of T cell proliferation; negative regulation of type II interferon production; positive regulation of bone mineralization; positive regulation of interleukin-2 production; positive regulation of osteoblast differentiation; positive regulation of T cell proliferation; positive regulation of type II interferon production; regulation of cytokine production; regulation of immune response; T cell activation; T cell proliferation; T cell receptor signaling pathway
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Reference #:
Q8VE98
(UniProtKB)
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Alt. Names/Synonyms: 6030411F23Rik; AU016588; B7 homolog 3; B7-H3; B7h3; B7RP; B7RP-2; Cd276; CD276 antigen; Costimulatory molecule
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Gene Symbols: Cd276
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Molecular weight:
34,001 Da
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Basal Isoelectric point:
4.68
Predict pI for various phosphorylation states
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