hnRNP A1 Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear export; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  catalytic step 2 spliceosome; cytoplasm; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex
Molecular Function:  G-rich strand telomeric DNA binding; miRNA binding; pre-mRNA binding; protein binding; protein domain specific binding; single-stranded DNA binding; single-stranded RNA binding; telomeric repeat-containing RNA binding
Biological Process:  cellular response to glucose starvation; cellular response to sodium arsenite; fibroblast growth factor receptor signaling pathway; import into nucleus; mRNA splicing, via spliceosome; mRNA transport; negative regulation of telomere maintenance via telomerase; nuclear export; positive regulation of telomere maintenance via telomerase; regulation of alternative mRNA splicing, via spliceosome; RNA export from nucleus; RNA metabolic process; viral process
Disease: Amyotrophic Lateral Sclerosis 20; Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 3
Reference #:  P09651 (UniProtKB)
Alt. Names/Synonyms: Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP core protein A1; hnRNP-A1; HNRNPA1; HNRPA1; MGC102835; nuclear ribonucleoprotein particle A1 protein; ROA1; single-strand DNA-binding protein UP1; Single-strand RNA-binding protein
Gene Symbols: HNRNPA1
Molecular weight: 38,747 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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hnRNP A1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene