hnRNP A1 Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. (Microbial infection) May play a role in HCV RNA replication. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear export; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of human Ortholog: 12q13.13
Cellular Component:  catalytic step 2 spliceosome; cytoplasm; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex
Molecular Function:  G-rich strand telomeric DNA binding; miRNA binding; pre-mRNA binding; protein binding; protein domain specific binding; single-stranded DNA binding; single-stranded RNA binding; telomeric repeat-containing RNA binding
Biological Process:  cellular response to glucose starvation; cellular response to sodium arsenite; fibroblast growth factor receptor signaling pathway; import into nucleus; mRNA splicing, via spliceosome; mRNA transport; negative regulation of telomere maintenance via telomerase; nuclear export; positive regulation of telomere maintenance via telomerase; regulation of alternative mRNA splicing, via spliceosome; RNA export from nucleus; RNA metabolic process; viral process
Disease: Amyotrophic Lateral Sclerosis 20; Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 3
Reference #:  P09651 (UniProtKB)
Alt. Names/Synonyms: ALS19; ALS20; epididymis secretory sperm binding protein; Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP core protein A1; hnRNP core protein A1-like 3; hnRNP-A1; HNRNPA1; HNRPA1; HNRPA1L3; IBMPFD3; MGC102835; nuclear ribonucleoprotein particle A1 protein; putative heterogeneous nuclear ribonucleoprotein A1-like 3; ROA1; single-strand DNA-binding protein UP1; Single-strand RNA-binding protein; UP 1
Gene Symbols: HNRNPA1
Molecular weight: 38,747 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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hnRNP A1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene