Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear export; RNA splicing; RNA-binding; Spliceosome
Molecular Function: G-rich strand telomeric DNA binding; miRNA binding; pre-mRNA binding; protein binding; protein domain specific binding; single-stranded DNA binding; single-stranded RNA binding; telomeric repeat-containing RNA binding
Biological Process: cellular response to glucose starvation; cellular response to sodium arsenite; fibroblast growth factor receptor signaling pathway; import into nucleus; mRNA splicing, via spliceosome; mRNA transport; negative regulation of telomere maintenance via telomerase; nuclear export; positive regulation of telomere maintenance via telomerase; regulation of alternative mRNA splicing, via spliceosome; RNA export from nucleus; RNA metabolic process; viral process