cIAP1 Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. Belongs to the IAP family. Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 11q22.2
Cellular Component:  CD40 receptor complex; cytoplasm; cytoplasmic side of plasma membrane; cytosol; nucleus; XY body
Molecular Function:  cysteine-type endopeptidase inhibitor activity involved in apoptotic process; FBXO family protein binding; identical protein binding; protein binding; protein-containing complex binding; protein-folding chaperone binding; transcription coactivator activity; transferase activity; ubiquitin binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  apoptotic process; cell surface receptor signaling pathway; I-kappaB kinase/NF-kappaB signaling; necroptotic process; negative regulation of apoptotic process; negative regulation of necroptotic process; negative regulation of ripoptosome assembly involved in necroptotic process; NIK/NF-kappaB signaling; placenta development; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein K48-linked ubiquitination; positive regulation of protein K63-linked ubiquitination; positive regulation of protein monoubiquitination; positive regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of apoptotic process; regulation of cell cycle; regulation of cell differentiation; regulation of cell population proliferation; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of innate immune response; regulation of necroptotic process; regulation of NIK/NF-kappaB signaling; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of reactive oxygen species metabolic process; regulation of RIG-I signaling pathway; regulation of toll-like receptor signaling pathway; response to cAMP; response to ethanol; response to hypoxia; tumor necrosis factor-mediated signaling pathway
Reference #:  Q13490 (UniProtKB)
Alt. Names/Synonyms: API1; apoptosis inhibitor 1; baculoviral IAP repeat containing 2; baculoviral IAP repeat-containing 2; Baculoviral IAP repeat-containing protein 2; BIRC2; C-IAP1; Cellular inhibitor of apoptosis 1; cIAP1; hIAP-2; hIAP2; IAP homolog B; IAP-2; IAP2; Inhibitor of apoptosis protein 2; MIHB; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; RNF48; TNFR2-TRAF-signaling complex protein 2
Gene Symbols: BIRC2
Molecular weight: 69,900 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein