ENO1 a multifunctional enzyme and abundant cytoplasmic protein. Plays a role in glycolysis as well as various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. Belongs to the enolase family. The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Lyase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p36.23
Cellular Component:  cell cortex region; cell surface; cytoplasm; cytosol; M band; membrane; nucleus; phosphopyruvate hydratase complex; plasma membrane
Molecular Function:  DNA-binding transcription repressor activity, RNA polymerase II-specific; GTPase binding; magnesium ion binding; phosphopyruvate hydratase activity; protein binding; protein homodimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  canonical glycolysis; gluconeogenesis; negative regulation of cell growth; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of ATP biosynthetic process; positive regulation of muscle contraction; positive regulation of plasminogen activation; response to virus
Reference #:  P06733 (UniProtKB)
Alt. Names/Synonyms: 2-phospho-D-glycerate hydro-lyase; alpha enolase like 1; Alpha-enolase; C-myc promoter-binding protein; ENO1; ENO1L1; ENOA; Enolase 1; enolase 1, (alpha); MBP-1; MBPB1; MPB-1; MPB1; MYC promoter-binding protein 1; NNE; Non-neural enolase; Phosphopyruvate hydratase; Plasminogen-binding protein; PPH; tau-crystallin
Gene Symbols: ENO1
Molecular weight: 47,169 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ENO1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene