CD3E Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 11q23.3
Cellular Component:  cell body; cell-cell junction; dendritic spine; external side of plasma membrane; immunological synapse; integral component of plasma membrane; plasma membrane; T cell receptor complex
Molecular Function:  protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; receptor signaling complex scaffold activity; SH3 domain binding; T cell receptor binding; transmembrane signaling receptor activity
Biological Process:  adaptive immune response; apoptotic signaling pathway; cell surface receptor signaling pathway; cerebellum development; dendrite development; G protein-coupled receptor signaling pathway; negative regulation of gene expression; negative regulation of smoothened signaling pathway; negative thymic T cell selection; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of cell-matrix adhesion; positive regulation of gene expression; positive regulation of interferon-gamma production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell anergy; positive regulation of T cell proliferation; protein homooligomerization; protein-containing complex assembly; regulation of apoptotic process; regulation of immune response; response to nutrient; signal complex assembly; T cell activation; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Immunodeficiency 18
Reference #:  P07766 (UniProtKB)
Alt. Names/Synonyms: CD3-epsilon; CD3E; CD3E antigen, epsilon polypeptide; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; FLJ18683; IMD18; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3E; TCRE
Gene Symbols: CD3E
Molecular weight: 23,147 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene