CD3E Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 11q23.3
Cellular Component:  alpha-beta T cell receptor complex; cell body; cell-cell junction; dendritic spine; endoplasmic reticulum; external side of plasma membrane; gamma-delta T cell receptor complex; Golgi apparatus; immunological synapse; plasma membrane; T cell receptor complex
Molecular Function:  identical protein binding; protein binding; protein kinase binding; SH3 domain binding; signaling receptor complex adaptor activity; T cell receptor binding; transmembrane signaling receptor activity
Biological Process:  adaptive immune response; alpha-beta T cell activation; apoptotic signaling pathway; calcium-mediated signaling; CD4-positive, alpha-beta T cell proliferation; cell surface receptor signaling pathway; cerebellum development; dendrite development; G protein-coupled receptor signaling pathway; gamma-delta T cell activation; negative regulation of gene expression; negative regulation of smoothened signaling pathway; negative thymic T cell selection; peptidyl-tyrosine phosphorylation; positive regulation of calcium-mediated signaling; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of cell-matrix adhesion; positive regulation of gene expression; positive regulation of interleukin-2 production; positive regulation of interleukin-4 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell anergy; positive regulation of T cell proliferation; positive regulation of type II interferon production; positive thymic T cell selection; protein-containing complex assembly; regulation of apoptotic process; signal complex assembly; smoothened signaling pathway; T cell activation; T cell anergy; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Immunodeficiency 18
Reference #:  P07766 (UniProtKB)
Alt. Names/Synonyms: CD3-epsilon; CD3E; CD3E antigen, epsilon polypeptide; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; FLJ18683; IMD18; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3E; TCRE
Gene Symbols: CD3E
Molecular weight: 23,147 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CD3E

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein