PLCG2 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of Human Ortholog: 8 E1|8 64.26 cM
Cellular Component:  cytosol; membrane; plasma membrane
Molecular Function:  hydrolase activity; phosphatidylinositol phospholipase C activity; phospholipase C activity; phosphoric diester hydrolase activity; phosphotyrosine residue binding; protein binding
Biological Process:  activation of store-operated calcium channel activity; B cell differentiation; B cell receptor signaling pathway; follicular B cell differentiation; inositol trisphosphate biosynthetic process; intracellular signal transduction; lipid catabolic process; lipid metabolic process; negative regulation of programmed cell death; phosphatidylinositol biosynthetic process; phosphatidylinositol-mediated signaling; phospholipid catabolic process; positive regulation of cytosolic calcium ion concentration; positive regulation of receptor internalization; positive regulation of type I interferon production; regulation of gene expression; release of sequestered calcium ion into cytosol; response to ATP; response to lipopolysaccharide; response to magnesium ion; signal transduction; T cell receptor signaling pathway
Reference #:  Q8CIH5 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; MGC38590; Phosphoinositide phospholipase C-gamma-2; phospholipase C, gamma 2; Phospholipase C-gamma-2; PLC-gamma-2; Plcg; Plcg-2; Plcg2; PLCga; PLCgamma2
Gene Symbols: Plcg2
Molecular weight: 147,592 Da
Basal Isoelectric point: 6.34  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene