SHP-2 Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Widely expressed, with highest levels in heart, brain, and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  cell junction; cytoplasm; cytosol; membrane; mitochondrion; nucleus; protein-containing complex; stress fiber
Molecular Function:  cell adhesion molecule binding; D1 dopamine receptor binding; hydrolase activity; insulin receptor binding; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; peptide hormone receptor binding; phosphatase activity; phospholipase binding; phosphoprotein phosphatase activity; phosphotyrosine residue binding; protein binding; protein domain specific binding; protein kinase binding; protein tyrosine kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity
Biological Process:  abortive mitotic cell cycle; activation of MAPK activity; atrioventricular canal development; axonogenesis; Bergmann glial cell differentiation; brain development; cellular response to epidermal growth factor stimulus; cellular response to mechanical stimulus; cerebellar cortex formation; dephosphorylation; DNA damage checkpoint; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; ERBB signaling pathway; face morphogenesis; genitalia development; glucose homeostasis; heart development; homeostasis of number of cells within a tissue; hormone metabolic process; hormone-mediated signaling pathway; inner ear development; integrin-mediated signaling pathway; intestinal epithelial cell migration; lipid metabolic process; megakaryocyte development; microvillus organization; multicellular organism growth; multicellular organismal reproductive process; negative regulation of cell adhesion mediated by integrin; negative regulation of cortisol secretion; negative regulation of growth hormone secretion; negative regulation of hormone secretion; negative regulation of insulin secretion; neurotrophin TRK receptor signaling pathway; organ growth; peptidyl-tyrosine dephosphorylation; platelet formation; platelet-derived growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of glucose import; positive regulation of hormone secretion; positive regulation of insulin receptor signaling pathway; positive regulation of interferon-beta production; positive regulation of interleukin-6 production; positive regulation of mitotic cell cycle; positive regulation of signal transduction; positive regulation of tumor necrosis factor production; protein dephosphorylation; regulation of cell adhesion mediated by integrin; regulation of protein complex assembly; regulation of protein export from nucleus; triglyceride metabolic process
Reference #:  P35235 (UniProtKB)
Alt. Names/Synonyms: 2700084A17Rik; AW536184; protein tyrosine phosphatase, non-receptor type 11; Protein-tyrosine phosphatase SYP; PTN11; PTP; PTP1D; PTP2C; Ptpn11; SAP-2; SH-P; SH-PTP2; SH-PTP3; SH2 domain-containing protein tyrosine phosphatase-2; SHP; SHP-2; Shp2; Syp; Tyrosine-protein phosphatase non-receptor type 11
Gene Symbols: Ptpn11
Molecular weight: 68,035 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  IL6 Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene