CHD-1 ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity. Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells. Belongs to the SNF2/RAD54 helicase family. Expressed in many tissues including in the brain, where the highest level of expression is found in the cerebellum and basal ganglia. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase
Chromosomal Location of Human Ortholog: 5q15-q21.1
Cellular Component:  cytoplasm; fibrillar center; nucleoplasm; nucleus
Molecular Function:  ATP binding; ATP-dependent DNA helicase activity; DNA binding; methylated histone binding; protein binding
Biological Process:  chromatin remodeling; covalent chromatin modification; DNA duplex unwinding; positive regulation by host of viral transcription; regulation of transcription by RNA polymerase II
Disease: Pilarowski-bjornsson Syndrome
Reference #:  O14646 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase CHD1; CHD-1; CHD1; chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1; DKFZp686E2337; PILBOS
Gene Symbols: CHD1
Molecular weight: 196,688 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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