Cas-L a widely expressed docking protein which plays a central coordinating role for tyrosine-kinase-based signaling in cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Phosphorylated following integrin beta-1, antigen receptor, or C1a calcitonin receptor signaling. Transformation of fibroblasts with v-ABL results in an increase in its tyrosine phosphorylation. Phosphorylated by focal adhesion kinase. Highly expressed in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13|13 A3.3-A4
Cellular Component:  cytoplasm; cytoskeleton; cytosol; nucleoplasm; nucleus; plasma membrane; spindle pole
Molecular Function:  protein binding; protein tyrosine kinase binding
Biological Process:  actin filament reorganization; activation of GTPase activity; cell adhesion; cell cycle; cell division; cell migration; positive regulation of cell migration; positive regulation of protein tyrosine kinase activity; positive regulation of substrate adhesion-dependent cell spreading; regulation of growth
Reference #:  O35177 (UniProtKB)
Alt. Names/Synonyms: CAS-L; Casl; Crk-associated substrate lymphocyte-specific protein; CRK-associated substrate-related protein; E230025G09Rik; Enhancer of filamentation 1; HEF1; mEF1; NEDD-9; Nedd9; Neural precursor cell expressed developmentally down-regulated protein 9; neural precursor cell expressed, developmentally down-regulated gene 9; p105
Gene Symbols: Nedd9
Molecular weight: 93,052 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cas-L

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene