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Cas-L
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Belongs to the CAS family. Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 6p24.2 |
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Cellular Component:
basolateral plasma membrane; cell cortex; ciliary basal body; cytoplasm; cytosol; focal adhesion; Golgi apparatus; immunological synapse; lamellipodium; mitotic spindle; nucleoplasm; nucleus; plasma membrane; spindle; spindle pole
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Molecular Function:
protein binding; protein tyrosine kinase binding
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Biological Process:
actin filament bundle assembly; actin filament reorganization; activation of GTPase activity; cell adhesion; cell cycle; cell division; cell migration; cilium disassembly; cytoskeleton organization; integrin-mediated signaling pathway; learning or memory; lymphocyte migration into lymphoid organs; negative regulation of cell migration; positive regulation of cell migration; positive regulation of dendritic spine maintenance; positive regulation of immunological synapse formation; positive regulation of lymphocyte chemotaxis; positive regulation of osteoclast differentiation; positive regulation of protein localization; positive regulation of protein tyrosine kinase activity; positive regulation of substrate adhesion-dependent cell spreading; regulation of actin cytoskeleton organization; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q14511
(UniProtKB)
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Alt. Names/Synonyms: Cas scaffolding protein family member 2; CAS-L; cas-like docking; CAS2; CASL; CASS2; Crk-associated substrate related; Crk-associated substrate related protein Cas-L; CRK-associated substrate-related protein; dJ49G10.2; dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)); dJ761I2.1; dJ761I2.1 (enhancer of filamentation (HEF1)); Enhancer of filamentation 1; Enhancer of filamentation 1 p55; hEF1; NEDD-9; NEDD9; Neural precursor cell expressed developmentally down-regulated protein 9; neural precursor cell expressed, developmentally down-regulated 9; p105; p130Cas-related protein; Renal carcinoma antigen NY-REN-12
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Gene Symbols: NEDD9
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Molecular weight:
92,861 Da
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Basal Isoelectric point:
6.23
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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