plakophilin 4 an armadillo-like protein of the beta-catenin family. A component of desmosomal plaques and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Two splice-variant isoforms have been described Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 2q24.1
Cellular Component:  cell junction; cell-cell junction; cornified envelope; cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; desmosome; midbody; mitotic spindle; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; spindle midzone; spindle pole
Molecular Function:  protein binding
Biological Process:  cell-cell junction assembly; cell-cell signaling; cornification; keratinization; positive regulation of cytokinesis; positive regulation of GTPase activity; regulation of cell adhesion
Reference #:  Q99569 (UniProtKB)
Alt. Names/Synonyms: catenin 4; FLJ31261; FLJ42243; p0071; PKP4; plakophilin 4; Plakophilin-4
Gene Symbols: PKP4
Molecular weight: 131,868 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
Select Structure to View Below

plakophilin 4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein