SHIP-2 an SH2-containing inositol phosphatase. Recruited to activated receptor complexes including insulin R, PDGFR and Fc-gamma-R. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Motility/polarity/chemotaxis; Phosphatase, lipid
Chromosomal Location of Human Ortholog: 7|7 E2
Cellular Component:  cell projection; cytoplasm; cytoskeleton; cytosol; Golgi apparatus; lamellipodium; membrane; plasma membrane
Molecular Function:  actin binding; hydrolase activity; inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate binding; protein binding; SH2 domain binding; SH3 domain binding
Biological Process:  actin filament organization; cell adhesion; cellular lipid metabolic process; endochondral ossification; endocytosis; glucose metabolic process; immune system process; inositol trisphosphate metabolic process; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of gene expression; negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor signaling pathway; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; post-embryonic development; response to insulin; ruffle assembly
Reference #:  Q6P549 (UniProtKB)
Alt. Names/Synonyms: 51C; AblSH3-binding protein; inositol polyphosphate phosphatase-like 1; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Inppl1; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SHIP-2; Ship2
Gene Symbols: Inppl1
Molecular weight: 138,973 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene