STMN1 Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. Belongs to the stathmin family. Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 5q36
Cellular Component:  cytoplasm; cytosol; membrane; microtubule; neuron projection
Molecular Function:  tubulin binding
Biological Process:  axonogenesis; brain development; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; intracellular signal transduction; microtubule depolymerization; mitotic cytokinesis; mitotic spindle organization; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of microtubule polymerization; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; neuron projection development; positive regulation of cellular component movement; regulation of cytoskeleton organization; regulation of microtubule polymerization or depolymerization; response to virus
Reference #:  P13668 (UniProtKB)
Alt. Names/Synonyms: Lap18; leukemia-associated cytosolic phosphoprotein stathmin; Leukemia-associated phosphoprotein p18; Metablastin; MGC72884; Oncoprotein 18; Op18; Phosphoprotein p19; pp17; pp19; PR22; Pr22 protein; Prosolin; SMN; Stathmin; stathmin 1; Stmn1
Gene Symbols: Stmn1
Molecular weight: 17,288 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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STMN1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene