p21Cip1 May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding. Belongs to the CDI family. Expressed in all adult tissues, with 5-fold lower levels observed in the brain. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Inhibitor
Cellular Component: 
Reference #:  Q683K8 (UniProtKB)
Alt. Names/Synonyms: p21Cip1; Putative cyclin-dependent kinase inhibitor 1A (P21/WAF1/CIP1)
Gene Symbols: cdkn1a
Molecular weight: 14,548 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  G1/S Checkpoint  |  G2/M DNA Damage Checkpoint  |  PI3K/Akt Signaling
Select Structure to View Below

p21Cip1

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  GeneCards  |  UniProtKB