NFAT2 Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum. 10 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 18 E3|18 53.66 cM
Cellular Component:  cytoplasm; cytosol; nuclear body; nuclear chromatin; nuclear transcription factor complex; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase p38 binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription coactivator binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; transcription factor binding
Biological Process:  aortic valve morphogenesis; B-1a B cell differentiation; branching involved in lymph vessel morphogenesis; calcineurin-NFAT signaling cascade; calcium ion transport; cytokine production; epithelial to mesenchymal transition; G1/S transition of mitotic cell cycle; heart development; heart trabecula morphogenesis; heart valve morphogenesis; intracellular signal transduction; lymphangiogenesis; negative regulation of osteoblast differentiation; negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of vascular smooth muscle cell differentiation; osteoclast differentiation; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; pulmonary valve morphogenesis; regulation of hair cycle; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transition between fast and slow fiber; ventricular septum morphogenesis
Reference #:  O88942 (UniProtKB)
Alt. Names/Synonyms: 2210017P03Rik; AI449492; AV076380; NF-A; NF-ATc; NF-ATc1; NFA; NFAC1; NFAT transcription complex cytosolic component; Nfat2; NFATc; NFATc1; Nfatcb; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; Nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; transcription factor NF-ATc
Gene Symbols: Nfatc1
Molecular weight: 77,833 Da
Basal Isoelectric point: 7.64  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene