NFAT2 Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum. 10 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 18q23
Cellular Component:  chromatin; cytoplasm; cytosol; nuclear body; nucleoplasm; nucleus; transcription regulator complex
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; FK506 binding; mitogen-activated protein kinase p38 binding; nucleic acid binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding; transcription coactivator binding; transcription factor binding
Biological Process:  aortic valve morphogenesis; calcineurin-NFAT signaling cascade; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; cytokine production; intracellular signal transduction; mononuclear cell differentiation; negative regulation of vascular associated smooth muscle cell differentiation; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; pulmonary valve morphogenesis; regulation of transcription by RNA polymerase II
Reference #:  O95644 (UniProtKB)
Alt. Names/Synonyms: MGC138448; NF-ATc; NF-ATc1; NF-ATc1.2; NFAC1; NFAT transcription complex cytosolic component; NFAT2; NFATC; NFATC1; nuclear factor of activated T cells 1; nuclear factor of activated T-cells 'c'; Nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Gene Symbols: NFATC1
Molecular weight: 101,243 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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