NFAT3 Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4. Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function. Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC. Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation. In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival. Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP). Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes. Binds the consensus DNA sequence 5'-GGAAAAT-3'. In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity. Binds to PPARG and REG3G gene promoters. Widely expressed, with high levels in placenta, lung, kidney, testis and ovary (PubMed:18675896). Weakly expressed in spleen and thymus (PubMed:18675896). In the hippocampus, expressed in the granular layer of the dentate gyrus, in the pyramidal neurons of CA3 region, and in the hippocampal fissure (PubMed:18675896). Expressed in the heart (at protein level) (PubMed:12370307). 24 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14q12
Cellular Component:  cytosol; nuclear speck; nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; peroxisome proliferator activated receptor binding; protein binding; transcription coactivator activity
Biological Process:  brain-derived neurotrophic factor receptor signaling pathway; branching involved in blood vessel morphogenesis; cellular respiration; cellular response to ionomycin; cellular response to lithium ion; cellular response to UV; heart development; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage; long-term memory; long-term synaptic potentiation; muscle cell development; negative regulation of chromatin binding; negative regulation of dendrite morphogenesis; negative regulation of neuron apoptotic process; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of protein binding; negative regulation of synapse maturation; negative regulation of Wnt signaling pathway; positive regulation of apoptotic signaling pathway; positive regulation of tumor necrosis factor production; smooth muscle cell differentiation; transcription by RNA polymerase II
Reference #:  Q14934 (UniProtKB)
Alt. Names/Synonyms: NF-AT3; NF-ATc4; NFAC4; NFAT3; NFATC4; nuclear factor of activated T cells 4; Nuclear factor of activated T-cells, cytoplasmic 4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; T cell transcription factor NFAT3; T-cell transcription factor NFAT3
Gene Symbols: NFATC4
Molecular weight: 95,449 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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