NFAT4 Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. Along with NFATC4, involved in embryonic heart development. Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 8 D3|8 53.08 cM
Cellular Component:  cytoplasm; cytosol; nuclear transcription factor complex; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; proximal promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding
Biological Process:  blood vessel remodeling; branching involved in blood vessel morphogenesis; calcineurin-NFAT signaling cascade; cardiac muscle hypertrophy in response to stress; cellular respiration; cellular response to calcium ion; cellular response to lithium ion; cytokine production; heart development; multicellular organism development; muscle cell development; myotube cell development; myotube differentiation; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of vascular smooth muscle cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of store-operated calcium entry; regulation of transcription, DNA-templated; response to hypoxia; skeletal muscle fiber development; smooth muscle cell differentiation; T cell differentiation; thymus development
Reference #:  P97305 (UniProtKB)
Alt. Names/Synonyms: C80703; D8Ertd281; D8Ertd281e; NF-AT4; NF-ATc3; NFA; NFAC3; Nfat4; NFATc3; NFATx; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3; Nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T-cell transcription factor NFAT4
Gene Symbols: Nfatc3
Molecular weight: 115,451 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene