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PRMT8
S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer. Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT8 subfamily. Brain-specific. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.1.1.-; Methyltransferase; Methyltransferase, protein arginine |
| Chromosomal Location of human Ortholog: 12p13.32 |
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Cellular Component:
cytoplasmic side of plasma membrane; nucleus; plasma membrane
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Molecular Function:
enzyme binding; histone arginine N-methyltransferase activity; identical protein binding; protein binding; protein homodimerization activity; protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; S-adenosyl-L-methionine binding; S-adenosylmethionine-dependent methyltransferase activity
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Biological Process:
histone methylation; peptidyl-arginine methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; protein homooligomerization; protein methylation; regulation of protein binding
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Reference #:
Q9NR22
(UniProtKB)
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Alt. Names/Synonyms: ANM8; arginine methyltransferase 8; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4; HMT1 hnRNP methyltransferase-like 3; HMT1 hnRNP methyltransferase-like 4; HRMT1L3; HRMT1L4; PRMT8; protein arginine methyltransferase 8; protein arginine N-methyltransferase 4; Protein arginine N-methyltransferase 8
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Gene Symbols: PRMT8
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Molecular weight:
45,291 Da
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Basal Isoelectric point:
6.47
Predict pI for various phosphorylation states
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