PhLP Acts as a positive regulator of hedgehog signaling and regulates ciliary function. Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin. Belongs to the phosducin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.
Chromosomal Location of Human Ortholog: 2|2 B
Cellular Component:  cell projection; cytoplasm
Molecular Function:  protein-containing complex binding
Biological Process:  cell projection organization; heterotrimeric G-protein complex assembly; negative regulation of protein refolding; positive regulation of smoothened signaling pathway; protein folding; response to stimulus; visual perception
Reference #:  Q9DBX2 (UniProtKB)
Alt. Names/Synonyms: 1200011E13Rik; AW108059; OTTMUSP00000013540; OTTMUSP00000013541; Pdcl; PHLP; phosducin-like; Phosducin-like protein
Gene Symbols: Pdcl
Molecular weight: 34,407 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene