PFKFB3 Synthesis and degradation of fructose 2,6-bisphosphate. In the C-terminal section; belongs to the phosphoglycerate mutase family. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 17q12.2
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  6-phosphofructo-2-kinase activity; ATP binding; fructose-2,6-bisphosphate 2-phosphatase activity
Biological Process:  brain development; carbohydrate phosphorylation; dephosphorylation; fructose 2,6-bisphosphate metabolic process; fructose metabolic process; regulation of glycolytic process
Reference #:  O35552 (UniProtKB)
Alt. Names/Synonyms: 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ase brain-type isozyme; F263; Fructose-2,6-bisphosphatase; PFK/FBPase 3; Pfkfb3; RB2K
Gene Symbols: Pfkfb3
Molecular weight: 63,676 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PFKFB3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene