GluR4 Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9 A1|9 2.46 cM
Cellular Component:  AMPA glutamate receptor complex; cell junction; cell projection; dendrite; dendritic spine; glutamatergic synapse; integral component of membrane; integral component of postsynaptic density membrane; kainate selective glutamate receptor complex; membrane; neuronal cell body; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; terminal bouton
Molecular Function:  AMPA glutamate receptor activity; identical protein binding; ion channel activity; ionotropic glutamate receptor activity; protein binding; signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  chemical synaptic transmission; ion transport; modulation of chemical synaptic transmission; positive regulation of synaptic transmission, glutamatergic
Reference #:  Q9Z2W8 (UniProtKB)
Alt. Names/Synonyms: AMPA-selective glutamate receptor 4; Glu; GluA4; Glur; GluR-4; GluR-D; GluR4; Gluralpha4; Glutamate receptor 4; glutamate receptor channel alpha 4; Glutamate receptor ionotropic, AMPA 4; glutamate receptor, ionotropic, AMPA4 (alpha 4); Gria4; spike wave 1; spk; spkw1
Gene Symbols: Gria4
Molecular weight: 100,847 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene