SPRY2 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Belongs to the sprouty family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q31.1
Cellular Component:  cytoskeleton; cytosol; membrane; microtubule; microtubule cytoskeleton; nucleus; plasma membrane; ruffle membrane
Molecular Function:  protein binding; protein kinase binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase inhibitor activity
Biological Process:  bud elongation involved in lung branching; cell fate commitment; cellular response to leukemia inhibitory factor; cellular response to vascular endothelial growth factor stimulus; establishment of mitotic spindle orientation; inner ear morphogenesis; lung growth; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of cell projection organization; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of GTPase activity; negative regulation of neurotrophin TRK receptor signaling pathway; negative regulation of peptidyl-threonine phosphorylation; negative regulation of vascular endothelial growth factor signaling pathway; positive regulation of cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein serine/threonine kinase activity; regulation of cell differentiation; sensory perception of sound
Disease: Iga Nephropathy, Susceptibility To, 3
Reference #:  O43597 (UniProtKB)
Alt. Names/Synonyms: hSPRY2; MGC23039; Protein sprouty homolog 2; sprouty 2; sprouty homolog 2 (Drosophila); Spry-2; SPRY2; SPY2
Gene Symbols: SPRY2
Molecular weight: 34,688 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SPRY2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene