SPRY2
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Belongs to the sprouty family. Note: This description may include information from UniProtKB.
|
Protein type: Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis |
Chromosomal Location of mouse Ortholog: 14 E2.3|14 56.16 cM |
Cellular Component:
actin cytoskeleton; cell projection; cytoplasm; cytoskeleton; cytosol; membrane; microtubule; microtubule cytoskeleton; microtubule end; nucleus; plasma membrane
|
Molecular Function:
molecular function inhibitor activity; protein binding; protein kinase binding; protein serine/threonine kinase activator activity; ubiquitin-protein transferase inhibitor activity
|
Biological Process:
animal organ development; branching morphogenesis of an epithelial tube; bud elongation involved in lung branching; cell fate commitment; cellular response to leukemia inhibitory factor; cellular response to vascular endothelial growth factor stimulus; ERK1 and ERK2 cascade; establishment of mitotic spindle orientation; fibroblast growth factor receptor signaling pathway; inner ear morphogenesis; lung development; lung growth; lung morphogenesis; multicellular organism development; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of cell projection organization; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of GTPase activity; negative regulation of lens fiber cell differentiation; negative regulation of MAP kinase activity; negative regulation of neurotrophin TRK receptor signaling pathway; negative regulation of peptidyl-threonine phosphorylation; negative regulation of protein ubiquitination; negative regulation of Ras protein signal transduction; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of vascular endothelial growth factor signaling pathway; positive regulation of cell migration; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling; regulation of signal transduction; respiratory system development; sensory perception of sound
|
Reference #:
Q9QXV8
(UniProtKB)
|
Alt. Names/Synonyms: Protein sprouty homolog 2; spro; sprouty homolog 2; sprouty homolog 2 (Drosophila); sprouty RTK signaling antagonist 2; sprouty2; Spry-2; Spry2; SPY2
|
Gene Symbols: Spry2
|
Molecular weight:
34,623 Da
|
Basal Isoelectric point:
8.72
Predict pI for various phosphorylation states
|
CST Pathways:
ErbB/HER Signaling
|
Growth And Differentiation Control by MAPKs
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|