RYR2 ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1q43
Cellular Component:  calcium channel complex; junctional sarcoplasmic reticulum membrane; membrane; plasma membrane; protein-containing complex; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; Z disc
Molecular Function:  calcium channel activity; calcium-induced calcium release activity; calcium-release channel activity; calmodulin binding; enzyme binding; identical protein binding; ion channel binding; protein binding; protein kinase A catalytic subunit binding; protein kinase A regulatory subunit binding; protein self-association; ryanodine-sensitive calcium-release channel activity; suramin binding
Biological Process:  BMP signaling pathway; calcium ion transport; calcium ion transport into cytosol; calcium-mediated signaling; calcium-mediated signaling using intracellular calcium source; canonical Wnt signaling pathway; cardiac muscle contraction; cardiac muscle hypertrophy; cell communication by electrical coupling involved in cardiac conduction; cellular calcium ion homeostasis; cellular response to caffeine; cellular response to epinephrine stimulus; detection of calcium ion; embryonic heart tube morphogenesis; establishment of protein localization to endoplasmic reticulum; ion transmembrane transport; left ventricular cardiac muscle tissue morphogenesis; positive regulation of calcium-transporting ATPase activity; positive regulation of heart rate; positive regulation of sequestering of calcium ion; positive regulation of the force of heart contraction; Purkinje myocyte to ventricular cardiac muscle cell signaling; regulation of atrial cardiac muscle cell action potential; regulation of AV node cell action potential; regulation of cardiac conduction; regulation of cardiac muscle contraction; regulation of cardiac muscle contraction by calcium ion signaling; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cytosolic calcium ion concentration; regulation of heart rate; regulation of SA node cell action potential; regulation of ventricular cardiac muscle cell action potential; release of sequestered calcium ion into cytosol; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to caffeine; response to hypoxia; response to muscle activity; response to muscle stretch; response to redox state; sarcoplasmic reticulum calcium ion transport; type B pancreatic cell apoptotic process; ventricular cardiac muscle cell action potential
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 2; Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy
Reference #:  Q92736 (UniProtKB)
Alt. Names/Synonyms: ARVC2; ARVD2; cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Cardiac muscle-type ryanodine receptor; hRYR-2; Ryanodine receptor 2; ryanodine receptor 2 (cardiac); RYR-2; RYR2; VTSIP
Gene Symbols: RYR2
Molecular weight: 564,567 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene