RYR2 Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily. Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1q43
Cellular Component:  calcium channel complex; junctional sarcoplasmic reticulum membrane; membrane; plasma membrane; protein-containing complex; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; Z disc
Molecular Function:  calcium channel activity; calcium-induced calcium release activity; calcium-release channel activity; calmodulin binding; enzyme binding; identical protein binding; ion channel binding; protein binding; protein kinase A catalytic subunit binding; protein kinase A regulatory subunit binding; protein self-association; ryanodine-sensitive calcium-release channel activity; suramin binding
Biological Process:  BMP signaling pathway; calcium ion transport; calcium ion transport into cytosol; calcium-mediated signaling; calcium-mediated signaling using intracellular calcium source; canonical Wnt signaling pathway; cardiac muscle contraction; cardiac muscle hypertrophy; cell communication by electrical coupling involved in cardiac conduction; cellular calcium ion homeostasis; cellular response to caffeine; cellular response to epinephrine stimulus; detection of calcium ion; embryonic heart tube morphogenesis; establishment of protein localization to endoplasmic reticulum; ion transmembrane transport; left ventricular cardiac muscle tissue morphogenesis; positive regulation of calcium-transporting ATPase activity; positive regulation of heart rate; positive regulation of sequestering of calcium ion; positive regulation of the force of heart contraction; Purkinje myocyte to ventricular cardiac muscle cell signaling; regulation of atrial cardiac muscle cell action potential; regulation of AV node cell action potential; regulation of cardiac conduction; regulation of cardiac muscle contraction; regulation of cardiac muscle contraction by calcium ion signaling; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cytosolic calcium ion concentration; regulation of heart rate; regulation of SA node cell action potential; regulation of ventricular cardiac muscle cell action potential; release of sequestered calcium ion into cytosol; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to caffeine; response to hypoxia; response to muscle activity; response to muscle stretch; response to redox state; sarcoplasmic reticulum calcium ion transport; type B pancreatic cell apoptotic process; ventricular cardiac muscle cell action potential
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 2; Ventricular Arrythmias Due To Cardiac Ryanodine Receptor Calcium Release Deficiency Syndrome; Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy
Reference #:  Q92736 (UniProtKB)
Alt. Names/Synonyms: ARVC2; ARVD2; cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Cardiac muscle-type ryanodine receptor; cardiac-type ryanodine receptor; hRYR-2; islet-type ryanodine receptor; kidney-type ryanodine receptor; Ryanodine receptor 2; ryanodine receptor 2 (cardiac); RyR; RYR-2; RYR2; Type 2 ryanodine receptor; VTSIP
Gene Symbols: RYR2
Molecular weight: 564,567 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene