VAV2 Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2 A3|2 19.36 cM
Cellular Component:  cytoplasm; plasma membrane
Molecular Function:  epidermal growth factor receptor binding; guanyl-nucleotide exchange factor activity; metal ion binding; phosphotyrosine residue binding; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  angiogenesis; cell migration; cell projection assembly; intracellular signal transduction; lamellipodium assembly; positive regulation of phosphatidylinositol 3-kinase activity; regulation of GTPase activity; regulation of Rho protein signal transduction; small GTPase mediated signal transduction
Reference #:  Q60992 (UniProtKB)
Alt. Names/Synonyms: 2810040F13Rik; AI847175; Guanine nucleotide exchange factor VAV2; OTTMUSP00000012940; vav 2 oncogene; VAV-2; Vav2
Gene Symbols: Vav2
Molecular weight: 99,915 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  T Cell Receptor Signaling
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VAV2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene