SUN2 As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Nuclear envelope
Chromosomal Location of human Ortholog: 22q13.1
Cellular Component:  condensed nuclear chromosome; endosome membrane; integral component of nuclear inner membrane; meiotic nuclear membrane microtubule tethering complex; nuclear chromosome, telomeric region; nuclear envelope; nuclear membrane
Molecular Function:  identical protein binding; lamin binding; microtubule binding; protein binding
Biological Process:  centrosome localization; cytoskeletal anchoring at nuclear membrane; meiotic cell cycle; mitotic spindle organization; nuclear envelope organization; nuclear matrix anchoring at nuclear membrane; nuclear migration; nuclear migration along microfilament; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration; positive regulation of cell migration
Reference #:  Q9UH99 (UniProtKB)
Alt. Names/Synonyms: FRIGG; KIAA0668; MGC133055; MGC133056; nuclear envelope protein; Protein unc-84 homolog B; Rab5-interacting protein; RAB5IP; Sad1 and UNC84 domain containing 2; Sad1 unc-84 domain protein 2; Sad1/unc-84 protein-like 2; SUN domain-containing protein 2; SUN2; unc-84 homolog B; UNC84B
Gene Symbols: SUN2
Molecular weight: 80,311 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein