APS Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. Belongs to the SH2B adapter family. Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5|5 G2
Cellular Component:  actin filament; cytoplasm; cytosol; membrane; plasma membrane; ruffle; stress fiber
Molecular Function:  identical protein binding; protein binding; SH3/SH2 adaptor activity; signaling adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  actin cytoskeleton organization; antigen receptor-mediated signaling pathway; B-1 B cell homeostasis; brown fat cell differentiation; cytokine-mediated signaling pathway; glucose homeostasis; insulin receptor signaling pathway; intracellular signal transduction; negative regulation of glucose import; nervous system development; regulation of immune response; regulation of metabolic process; regulation of Ras protein signal transduction; signal transduction
Reference #:  Q9JID9 (UniProtKB)
Alt. Names/Synonyms: Adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains; Aps; insulin receptor substrate 5; SH2 and PH domain-containing adapter protein APS; SH2B adapter protein 2; SH2B adaptor protein 2; Sh2b2
Gene Symbols: Sh2b2
Molecular weight: 66,557 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein