APS Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. Belongs to the SH2B adapter family. Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of rat Ortholog: 12q12
Cellular Component:  actin filament; cytoplasm; cytosol; plasma membrane; ruffle; stress fiber
Molecular Function:  identical protein binding; JAK pathway signal transduction adaptor activity; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  actin cytoskeleton organization; antigen receptor-mediated signaling pathway; B-1 B cell homeostasis; brown fat cell differentiation; cytokine-mediated signaling pathway; insulin receptor signaling pathway; intracellular signal transduction; nervous system development; positive regulation of signal transduction; regulation of immune response; regulation of JAK-STAT cascade; regulation of metabolic process; regulation of Ras protein signal transduction
Reference #:  Q9Z200 (UniProtKB)
Alt. Names/Synonyms: Adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains; Aps; SH2 and PH domain-containing adapter protein APS; SH2B adapter protein 2; SH2B adaptor protein 2; Sh2b2
Gene Symbols: Sh2b2
Molecular weight: 66,708 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene