TIF1A Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction. Belongs to the RRN3 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Transcription initiation complex
Chromosomal Location of Human Ortholog: 16p13.11
Cellular Component:  nucleolus; nucleoplasm; nucleus
Molecular Function:  RNA polymerase I CORE element sequence-specific DNA binding
Biological Process:  cell proliferation; cytoplasm organization; homeostasis of number of cells; in utero embryonic development; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; nucleolus organization; positive regulation of neuron projection development; positive regulation of transcription, DNA-templated; regulation of DNA-templated transcription, initiation; ribosome biogenesis; RNA polymerase I preinitiation complex assembly; transcription initiation from RNA polymerase I promoter
Reference #:  Q9NYV6 (UniProtKB)
Alt. Names/Synonyms: DKFZp566E104; MGC104238; RNA polymerase I-specific transcription initiation factor RRN3; RRN3; RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae); TIF-IA; TIF1A; TIFIA; Transcription initiation factor IA; transcription initiation factor TIF-IA
Gene Symbols: RRN3
Molecular weight: 74,107 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
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TIF1A

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein