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hnRNP C1/C2
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing. Belongs to the RRM HNRPC family. RALY subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of mouse Ortholog: 14 C2|14 26.79 cM |
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Cellular Component:
actin cytoskeleton; catalytic step 2 spliceosome; cytosol; nucleoplasm; nucleoplasmic periphery of the nuclear pore complex; nucleus; pronucleus; protein-containing complex; ribonucleoprotein complex; spliceosomal complex; telomerase holoenzyme complex
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Molecular Function:
deaminase binding; enzyme inhibitor activity; identical protein binding; mRNA 3'-UTR binding; mRNA binding; N6-methyladenosine-containing RNA binding; nucleic acid binding; poly(U) RNA binding; protein domain specific binding; ribonucleoprotein complex binding; RNA binding; telomerase RNA binding
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Biological Process:
3'-UTR-mediated mRNA stabilization; mRNA processing; mRNA splicing, via spliceosome; negative regulation of mRNA modification; negative regulation of telomere maintenance via telomerase; RNA splicing
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Reference #:
Q9Z204
(UniProtKB)
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Alt. Names/Synonyms: AL022939; D14Wsu171; D14Wsu171e; heterogeneous nuclear ribonucleoprotein C; heterogeneous nuclear ribonucleoprotein C1; heterogeneous nuclear ribonucleoprotein C2; Heterogeneous nuclear ribonucleoproteins C1/C2; heterogeneous ribonucleoprotein C1/C2; hnR; hnRNP C1 / hnRNP C2; hnRNP C1/C2; hnRNP C2; hnrnp-C; Hnrnpc; hnRNPC1; hnRNPC2; Hnrpc; Hnrpc1; Hnrpc2; snoRNA MBI-122
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Gene Symbols: Hnrnpc
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Molecular weight:
34,385 Da
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Basal Isoelectric point:
4.91
Predict pI for various phosphorylation states
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