|
MEK2
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.7.12.2; Kinase, protein; MEK3 subfamily; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family |
| Chromosomal Location of rat Ortholog: 7q11 |
|
Cellular Component:
cell cortex; cell-cell junction; cytoplasm; cytoplasmic side of plasma membrane; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; late endosome; microtubule; mitochondrion; nucleus; perinuclear region of cytoplasm
|
|
Molecular Function:
ATP binding; MAP kinase kinase activity; MAP-kinase scaffold activity; metal ion binding; molecular adaptor activity; PDZ domain binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding
|
|
Biological Process:
epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; heart development; insulin-like growth factor receptor signaling pathway; lung morphogenesis; MAPK cascade; negative regulation of gene expression; peptidyl-serine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of axonogenesis; positive regulation of cell motility; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein serine/threonine kinase activity; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; response to ischemia; thymus development; thyroid gland development; trachea formation
|
|
Reference #:
P36506
(UniProtKB)
|
|
Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; Map2k2; MAPK/ERK kinase 2; MAPKK 2; MEK 2; Mek2; mitogen activated protein kinase kinase 2; Mkk2; MP2K2; Prkmk2
|
|
Gene Symbols: Map2k2
|
|
Molecular weight:
44,282 Da
|
|
Basal Isoelectric point:
6.62
Predict pI for various phosphorylation states
|
|
CST Pathways:
Actin Dynamics
|
Angiogenesis
|
B Cell Receptor Signaling
|
ErbB/HER Signaling
|
ESC Pluripotency and Differentiation
|
GPCR Signaling to MAPKs
|
Growth And Differentiation Control by MAPKs
|
IL6 Signaling
|
Insulin Receptor Signaling
|
T Cell Receptor Signaling
|
Warburg Effect
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
