MKK6 a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 11|11 E1-E2
Cellular Component:  cytoplasm; cytoskeleton; cytosol; nucleus
Molecular Function:  ATP binding; identical protein binding; kinase activity; MAP kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  activation of MAPK activity; activation of protein kinase activity; apoptotic process; cardiac muscle contraction; MAPK cascade; negative regulation of cold-induced thermogenesis; phosphorylation; positive regulation of apoptotic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of protein phosphorylation; protein phosphorylation; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  P70236 (UniProtKB)
Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; Map2k6; MAPK/ERK kinase 6; MAPKK 6; MEK 6; MEK6; mitogen activated protein kinase kinase 6; mitogen-activated protein kinase kinase 6; MKK6; MP2K6; OTTMUSP00000003317; Prkmk6; protein kinase, mitogen activated, kinase 6; SAPKK3
Gene Symbols: Map2k6
Molecular weight: 37,432 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Regulation of P38 MAPKs  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene