MST4 Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; YSK subfamily
Chromosomal Location of mouse Ortholog: X|X A5
Cellular Component:  apical plasma membrane; cell periphery; cytoplasm; cytosol; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; membrane; perinuclear region of cytoplasm
Molecular Function:  ATP binding; identical protein binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of protein kinase activity; apoptotic process; cellular response to starvation; MAPK cascade; microvillus assembly; negative regulation of cell migration; neuron projection morphogenesis; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of apoptotic process; regulation of hydrogen peroxide-induced cell death; response to hydrogen peroxide; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q99JT2 (UniProtKB)
Alt. Names/Synonyms: 2610018G03Rik; Mammalian STE20-like protein kinase 4; Mst; MST-4; Mst3 and SOK1-related kinase; Mst4; OTTMUSP00000019070; RIKEN cDNA 2610018G03 gene; serine/threonine kinase 26; serine/threonine protein kinase MST4; Serine/threonine-protein kinase 26; Serine/threonine-protein kinase MST4; STE20-like kinase MST4; Stk26
Gene Symbols: Stk26
Molecular weight: 46,614 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MST4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein