SYNE1 iso4 Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. Belongs to the nesprin family. Expressed in HeLa, A431, A172 and HaCaT cells (at protein level). Widely expressed. Highly expressed in skeletal and smooth muscles, heart, spleen, peripheral blood leukocytes, pancreas, cerebellum, stomach, kidney and placenta. Isoform GSRP-56 is predominantly expressed in heart and skeletal muscle (at protein level). 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Membrane protein, integral; RNA-binding
Chromosomal Location of Human Ortholog: 6q25.2
Cellular Component:  cytoplasm; cytoskeleton; Golgi apparatus; integral component of membrane; meiotic nuclear membrane microtubule tethering complex; nuclear envelope; nuclear membrane; nuclear outer membrane; nucleolus; nucleoplasm; P-body; postsynaptic membrane; sarcomere
Molecular Function:  actin binding; actin filament binding; enzyme binding; lamin binding; protein binding; protein homodimerization activity
Biological Process:  cytoskeletal anchoring at nuclear membrane; Golgi organization; muscle cell differentiation; nuclear matrix anchoring at nuclear membrane; nucleus organization; spermatogenesis
Reference #:  Q8NF91-4 (UniProtKB)
Alt. Names/Synonyms: 8B; AMC3; AMCM; ARCA1; C6orf98; CPG2; CPG2 full length; dJ45H2.2; EDMD4; Enaptin; KASH domain-containing protein 1; KASH1; KIAA0796; KIAA1262; KIAA1756; Myne-1; MYNE1; Myocyte nuclear envelope protein 1; Nesp1; nesprin 1; Nesprin-1; Nuclear envelope spectrin repeat protein 1; SCAR8; spectrin repeat containing nuclear envelope protein 1; spectrin repeat containing, nuclear envelope 1; Synaptic nuclear envelope protein 1; synaptic nuclei expressed gene 1; Syne-1; SYNE1; SYNE1 iso4
Gene Symbols: SYNE1
Molecular weight: 1,005,181 Da
Basal Isoelectric point: 5.37  Predict pI for various phosphorylation states
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SYNE1 iso4

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein