FGFBP1 Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. Belongs to the fibroblast growth factor-binding protein family. Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 4p15.32
Cellular Component:  cell surface; extracellular region; extracellular space; plasma membrane
Molecular Function:  fibroblast growth factor binding; heparin binding; protein binding
Biological Process:  fibroblast growth factor receptor signaling pathway; negative regulation of cell proliferation; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of fibroblast growth factor receptor signaling pathway; signal transduction
Reference #:  Q14512 (UniProtKB)
Alt. Names/Synonyms: 17 kDa HBGF-binding protein; 17 kDa heparin-binding growth factor-binding protein; FGF-binding protein 1; FGF-BP; FGF-BP1; FGFBP; FGFBP-1; FGFBP1; FGFP1; fibroblast growth factor binding protein 1; Fibroblast growth factor-binding protein 1; HBP17; heparin-binding growth factor binding protein
Gene Symbols: FGFBP1
Molecular weight: 26,264 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
Select Structure to View Below

FGFBP1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB