YSK1 Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; YSK subfamily
Chromosomal Location of Human Ortholog: 1 D|1 47.25 cM
Cellular Component:  cytoplasm; Golgi membrane
Molecular Function:  ATP binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of protein kinase activity; establishment of Golgi localization; establishment or maintenance of cell polarity; Golgi localization; Golgi reassembly; intrinsic apoptotic signaling pathway in response to hydrogen peroxide; phosphorylation; positive regulation of axonogenesis; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphorylation; response to hydrogen peroxide; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q9Z2W1 (UniProtKB)
Alt. Names/Synonyms: 1500019J11Rik; AU018434; C86992; serine/threonine kinase 25 (Ste20, yeast homolog); serine/threonine kinase 25 (yeast); Serine/threonine-protein kinase 25; SOK-1; Sok1; Ste20-like; Ste20-like kinase; Ste20/oxidant stress response kinase 1; Sterile 20/oxidant stress-response kinase 1; Stk25; Yeast Sps1/Ste20-related kinase 1; Ysk1
Gene Symbols: Stk25
Molecular weight: 48,158 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
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YSK1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene