GluR2 iso2 Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of human Ortholog: 4q32.1

Cellular Component: AMPA glutamate receptor complex; asymmetric synapse; dendrite; dendritic spine; endocytic vesicle membrane; endoplasmic reticulum membrane; excitatory synapse; external side of plasma membrane; neuronal cell body; plasma membrane; postsynapse; postsynaptic density; postsynaptic density membrane; postsynaptic endocytic zone

Molecular Function: AMPA glutamate receptor activity; amyloid-beta binding; ionotropic glutamate receptor activity; protein binding; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Biological Process: chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; monoatomic ion transmembrane transport; regulation of postsynaptic membrane potential; signal transduction; synaptic transmission, glutamatergic

Reference #: P42262-2 (UniProtKB)

Alt. Names/Synonyms: AMPA-selective glutamate receptor 2; GluA2; gluR-2; gluR-B; GluR-K2; GluR2; GluR2 iso2; GLURB; glutamate ionotropic receptor AMPA type subunit 2; Glutamate receptor 2; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 2; GRIA2; HBGR2; NEDLIB

Gene Symbols: GRIA2

Molecular weight: 98,878 Da

Basal Isoelectric point: 7.81 Predict pI for various phosphorylation states

CST Pathways: Alzheimer's Disease | Parkinson's Disease

Select Structure to View Below
GluR2 iso2

Get PyMOL Script Get Chimera Script