PSD-93 iso3
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Belongs to the MAGUK family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold |
Chromosomal Location of human Ortholog: 11q14.1 |
Cellular Component:
adherens junction; axon cytoplasm; basolateral plasma membrane; cytosol; juxtaparanode region of axon; membrane; neuromuscular junction; neuron projection; perikaryon; plasma membrane; postsynaptic density; postsynaptic density membrane
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Molecular Function:
guanylate kinase activity; kinase binding; protein binding
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Biological Process:
anterograde axonal protein transport; cell-cell adhesion; cellular response to potassium ion; chemical synaptic transmission; embryo development; establishment or maintenance of epithelial cell apical/basal polarity; GDP metabolic process; GMP metabolic process; receptor clustering; receptor localization to synapse; retrograde axonal protein transport
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Reference #:
Q15700-3
(UniProtKB)
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Alt. Names/Synonyms: channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-110; discs large MAGUK scaffold protein 2; discs, large homolog 2, chapsyn-110; Disks large homolog 2; disks large homolog 2 isoform 3; DLG2; postsynaptic density protein PSD-93; PPP1R58; protein phosphatase 1, regulatory subunit 58; PSD-93; PSD-93 iso3; PSD93
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Gene Symbols: DLG2
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Molecular weight:
83,405 Da
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Basal Isoelectric point:
5.73
Predict pI for various phosphorylation states
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