TAO1 Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; TAO subfamily
Chromosomal Location of Human Ortholog: 10q24
Cellular Component:  cytoplasm; microtubule cytoskeleton; nucleus; perinuclear region of cytoplasm
Molecular Function:  alpha-tubulin binding; ATP binding; beta-tubulin binding; kinase activity; MAP kinase kinase kinase activity; myosin V binding; protein C-terminus binding; protein kinase activator activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity
Biological Process:  activation of MAPKK activity; activation of protein kinase activity; cellular response to DNA damage stimulus; DNA repair; execution phase of apoptosis; MAPK cascade; microtubule cytoskeleton organization; mitotic G2 DNA damage checkpoint; negative regulation of microtubule depolymerization; neuron cellular homeostasis; positive regulation of JNK cascade; positive regulation of protein acetylation; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of cytoskeleton organization; regulation of microtubule cytoskeleton organization; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  O88664 (UniProtKB)
Alt. Names/Synonyms: serine/threonine protein kinase TAO1; Serine/threonine-protein kinase TAO1; TAO kinase 1; Tao1; Taok1; Thousand and one amino acid protein 1
Gene Symbols: Taok1
Molecular weight: 115,952 Da
Basal Isoelectric point: 7.3  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Microtubule Dynamics  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Select Structure to View Below

TAO1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene