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TAO1
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; TAO subfamily |
| Chromosomal Location of rat Ortholog: 10q24 |
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Cellular Component:
cytoplasm; microtubule cytoskeleton; perinuclear region of cytoplasm
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Molecular Function:
alpha-tubulin binding; ATP binding; beta-tubulin binding; kinase activity; myosin V binding; protein binding; protein kinase activator activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity
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Biological Process:
central nervous system neuron development; DNA damage response; DNA repair; execution phase of apoptosis; microtubule cytoskeleton organization; mitotic G2 DNA damage checkpoint signaling; negative regulation of microtubule depolymerization; neuron cellular homeostasis; phosphorylation; positive regulation of JNK cascade; positive regulation of protein acetylation; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of cytoskeleton organization; regulation of microtubule cytoskeleton organization
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Reference #:
O88664
(UniProtKB)
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Alt. Names/Synonyms: serine/threonine protein kinase TAO1; Serine/threonine-protein kinase TAO1; TAO kinase 1; Tao1; Taok1; Thousand and one amino acid protein 1
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Gene Symbols: Taok1
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Molecular weight:
115,952 Da
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Basal Isoelectric point:
7.3
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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Microtubule Dynamics
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Regulation of P38 MAPKs
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SAPK/JNK Signaling Cascades
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