ataxin-7L3 iso2 Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B. Belongs to the SGF11 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component:  DUBm complex; nucleus; SAGA complex
Molecular Function:  nuclear receptor transcription coactivator activity; protein binding; transcription coactivator activity; zinc ion binding
Biological Process:  histone deubiquitination; histone monoubiquitination; positive regulation of transcription, DNA-templated
Reference #:  Q14CW9-2 (UniProtKB)
Alt. Names/Synonyms: ataxin 7-like 3; Ataxin-7-like protein 3; ataxin-7-like protein 3 isoform a; ATXN7L3; DKFZp761G2113; Q14CW9-2; SAGA-associated factor 11
Gene Symbols: ATXN7L3
Molecular weight: 39,599 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
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ataxin-7L3 iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein