TAO1 Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; TAO subfamily
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component:  cytosol; microtubule cytoskeleton; perinuclear region of cytoplasm
Molecular Function:  alpha-tubulin binding; ATP binding; beta-tubulin binding; kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity; transferase activity
Biological Process:  activation of JUN kinase activity; activation of MAPK activity; cellular response to DNA damage stimulus; DNA repair; execution phase of apoptosis; microtubule cytoskeleton organization; mitotic G2 DNA damage checkpoint; negative regulation of microtubule depolymerization; neuron cellular homeostasis; positive regulation of JNK cascade; positive regulation of protein acetylation; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of cytoskeleton organization; regulation of microtubule cytoskeleton organization
Reference #:  Q7L7X3 (UniProtKB)
Alt. Names/Synonyms: FLJ14314; hKFC-B; hTAOK1; KFC-B; KIAA1361; Kinase from chicken homolog B; MAP3K16; MARK Kinase; MARKK; microtubule affinity regulating kinase kinase; Prostate-derived STE20-like kinase 2; Prostate-derived sterile 20-like kinase 2; PSK-2; PSK2; serine/threonine kinase TAO1; serine/threonine protein kinase TAO1 homolog; Serine/threonine-protein kinase TAO1; STE20-like kinase PSK2; TAO kinase 1; TAO1; TAOK1; Thousand and one amino acid protein 1; Thousand and one amino acid protein kinase 1
Gene Symbols: TAOK1
Molecular weight: 116,070 Da
Basal Isoelectric point: 7.3  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Microtubule Dynamics  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene